Tolbutamide in Diabetes
نویسندگان
چکیده
منابع مشابه
The effects of tolbutamide on the myocardium in experimental diabetes.
The effects of chronic tolbutamide treatment were examined in a diabetic animal model in which abnormal myocardial function and composition have previously been demonstrated. Eight diabetic dogs were given tolbutamide 250 mg/day orally and compared with seven untreated diabetics, five healthy dogs receiving tolbutamide, and eight normal controls. After one year, resting hemodynamic studies in t...
متن کاملSerum tolbutamide and chlorpropamide concentrations in patients with diabetes mellitus.
A selective and sensitive gas chromatographic technique was used to measure the steady-state serum concentrations of tolbutamide and chlorpropamide in 97 patients with maturity-onset diabetes mellitus who had been taking these drugs (37 tolbutamide, 60 chlorpropamide) for at least a year. No other antidiabetic agents had been given. The serum tolbutamide concentrations varied widely between the...
متن کاملThe Effects of Tolbutamide
The effects of chronic tolbutamide treatment were examined in a diabetic animal model in which abnormal myocardial function and composition have previously been demonstrated. Eight diabetic dogs were given tolbutamide 250 mg/day orally and compared with seven untreated diabetics, five healthy dogs receiving tolbutamide, and eight normal controls. After one year, resting hemodynamic studies in t...
متن کاملHypoglycemic Effect Of Concomitant Administration Of Erythromycin And Tolbutamide In Alloxan-Induced Diabetes In Rats
Erythromycin is among the antibiotics that have widespread use for treatment of community and hospital-acquired infections. Although uncommon, hypoglycemia has been reported with erythromycin and appears to occur most frequently in elderly patients with type 2 diabetes mellitus who are receiving therapy with oral hypoglycemics. The present study was designed to explore the potential effects of ...
متن کاملHost-guest chemistry of tolbutamide.
The molecular recognition features of tolbutamide with four synthetic hosts have been studied by means of NMR titrations, NOESY experiments and Monte Carlo (MC) conformational search. The interaction strength and the most probable structure reveal new insights on the recognition phenomena of this urea derivative in comparison with close related compounds.
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ژورنال
عنوان ژورنال: BMJ
سال: 1957
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5040.327